Towards Rational de novo Design of Peptides for Inorganic Interfaces
نویسندگان
چکیده
Protein adsorption at inorganic surfaces is highly relevant to nanoand bionanotechnology. Just two examples of great significance are the use of specific peptide sequences to control cell deposition on tissue scaffolds, and the tethering of bio-photosynthetic reaction centers on electrodes to harvest light for power generation and hydrogen production. Understanding of the behavior of proteins in such situations and the design of surface-binding proteins for technological applications is currently limited by the largely empirical approaches used. We are, therefore, developing the application of molecular modeling to the elucidation of the behavior of peptides at fluid/solid interfaces – in this talk, we will provide details of these models and their application to the study of peptides at fluid/solid interfaces and their de novo rational design.
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